What’s new in non-Hodgkin lymphoma research and treatment?

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What’s new in non-Hodgkin lymphoma research and treatment?

Research into the causes, prevention, and treatment of non-Hodgkin lymphoma is being done in many medical centers throughout the world.

Genetics

Scientists are making a lot of progress in understanding how changes in DNA can cause normal lymphocytes to develop into lymphoma cells. This is providing insight into why these cells may grow too rapidly, live too long, and not develop into mature cells that take part in normal immune reactions. Once this is understood, drugs may be developed that block this process.

Progress in understanding DNA changes in lymphoma has already provided improved and highly sensitive tests for detecting this disease. Such tests can identify lymphoma cells based on changes such as chromosome translocations or rearrangements or specific gene mutations. Some of these tests are already in use, and others are being developed. They may be used to:

  • Detect lymphoma cells in a biopsy sample
  • Determine what type of lymphoma a person has
  • Help determine if a lymphoma is likely to grow and spread, even within a certain subtype of lymphoma
  • Help figure out if a certain treatment is likely to be helpful
  • Help determine if a lymphoma has been destroyed by treatment and if a relapse is likely

Treatment

Much of the research being done on non-Hodgkin lymphoma is focused on looking at new …

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